The Council for International Organizations of Medical Sciences CIOMS defines Adverse Event of Special Interest as An adverse event of special interest serious or non-serious is one of scientific and medical concern specific to the sponsors product or programme for which ongoing monitoring and rapid communication by the investigator to the sponsor may. This article provides clinically oriented recommendations for the management of leg edema in adults.
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We were unable to find existing practice guidelines that address this problem in a comprehensive manner.
. A common challenge for primary care physicians is to determine the cause and find an effective treatment for leg edema of unclear etiology. We searched on-line resources.
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